Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 9/20 | 0.57 |
| ▸ | FNTB | P49356 | 9/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CASR | P41180 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7995264 | 0.81 | GABBR2 (0.63) | FNTAFNTBKMT2A | |
| SCHEMBL10952833 | 0.81 | HTT (0.58) | FNTAFNTBALDH1A1HPGDCNR1 | |
| SCHEMBL19154393 | 0.80 | FNTA (0.51) | FNTAFNTBALDH1A1HPGDCNR1 | |
| SCHEMBL1999366 | 0.79 | LMNA (0.57) | FNTAFNTBALDH1A1KMT2A | |
| SCHEMBL17356383 | 0.79 | FNTA (0.84) | FNTAFNTBALDH1A1KMT2A | |
| SCHEMBL655571 | 0.74 | FNTA (0.93) | FNTAFNTB | |
| SCHEMBL12442271 | 0.73 | FNTA (0.68) | FNTAFNTBALDH1A1HDAC3HDAC4 | |
| SCHEMBL27818037 | 0.72 | FNTA (0.56) | FNTAFNTBALDH1A1HPGDCNR1 | |
| SCHEMBL7278612 | 0.72 | HDAC3 (0.59) | FNTAFNTBALDH1A1HPGDHDAC3 | |
| SCHEMBL12617213 | 0.72 | FNTA (0.58) | FNTAFNTBALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210121427-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | H LEE MOFFITT CANCER CT & RES (US) | 2021-04-29 | — | — | US | disclosed |
| US-10806712-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2020-10-20 | — | — | US | disclosed |
| US-20190192461-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | H LEE MOFFITT CANCER CT & RES (US) | 2019-06-27 | — | — | US | disclosed |
| US-10226439-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2019-03-12 | — | — | US | disclosed |
| US-20170202795-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | H LEE MOFFITT CANCER CT & RES (US) | 2017-07-20 | — | — | US | disclosed |
| US-9604923-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | H.LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2017-03-28 | — | — | US | disclosed |
| US-20140329900-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2014-11-06 | — | — | US | disclosed |
| US-20110201576-A1 | Small molecule inhibitors of stat3 with anti-tumor activity | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE (US) | 2011-08-18 | — | — | US | disclosed |
| US-7960434-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-06-14 | — | — | US | disclosed |
| US-20090069420-A1 | Small molecule inhibitors of STAT3 with anti-tumor activity | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | US | disclosed |
| WO-2007136858-A2 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE (US) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170202795-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | STAT3, STAT1, STAT5A | FNTA 2310/4885FNTB 1660/4885ALDH1A1 3674/4885 |
| US-20210121427-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | STAT3, STAT1, STAT5A | FNTA 2310/4885FNTB 1660/4885ALDH1A1 3674/4885 |
| US-20110201576-A1 | Small molecule inhibitors of stat3 with anti-tumor activity | STAT3, STAT1, STAT5A | FNTA 2310/4885FNTB 1660/4885ALDH1A1 3674/4885 |
| US-20090069420-A1 | Small molecule inhibitors of STAT3 with anti-tumor activity | STAT3, STAT1, STAT5A | FNTA 2310/4885FNTB 1660/4885ALDH1A1 3674/4885 |
| US-20140329900-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | STAT3, STAT1, JAK2 | FNTA 1951/4885FNTB 1421/4885ALDH1A1 3626/4885 |
| US-20190192461-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | STAT3, STAT1, STAT5A | FNTA 2310/4885FNTB 1660/4885ALDH1A1 3674/4885 |
| US-10226439-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | STAT3, STAT1, STAT5A | FNTA 2310/4885FNTB 1660/4885ALDH1A1 3674/4885 |
| US-10806712-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | STAT3, STAT1, STAT5A | FNTA 2310/4885FNTB 1660/4885ALDH1A1 3674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.