Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 11/20 | 0.62 |
| ▸ | CDK2 | P24941 | 11/20 | 0.62 |
| ▸ | CDK5 | Q00535 | 9/20 | 0.62 |
| ▸ | GLS | O94925 | 5/20 | 0.57 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 3/20 | 0.54 |
| ▸ | CDK4 | P11802 | 3/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.54 |
| ▸ | CCND1 | P24385 | 3/20 | 0.54 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.54 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.54 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.54 |
| ▸ | CCND2 | P30279 | 1/20 | 0.54 |
| ▸ | CCND3 | P30281 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5836526 | 0.89 | CCNE1 (0.64) | CCNE1CDK2CDK5GLSCDK1 | |
| SCHEMBL20014231 | 0.87 | CCNE1 (0.58) | CCNE1CDK2CDK5GLSCDK1 | |
| SCHEMBL5835963 | 0.84 | CCNE1 (0.58) | CCNE1CDK2CDK5GLSCDK1 | |
| SCHEMBL20014219 | 0.84 | CCNE1 (0.52) | CCNE1CDK2CDK5GLSCDK1 | |
| SCHEMBL27578137 | 0.82 | CCNE1 (0.76) | CCNE1CDK2CDK5GLSCDK1 | |
| SCHEMBL13694242 | 0.82 | GLS (0.59) | CCNE1CDK2CDK5GLSCDK1 | |
| SCHEMBL27549850 | 0.79 | CCNE1 (0.77) | CCNE1CDK2CDK5GLSCDK1 | |
| SCHEMBL29645003 | 0.79 | CCNE1 (0.77) | CCNE1CDK2CDK5GLSCDK1 | |
| SCHEMBL20014202 | 0.79 | MAPT (0.56) | CCNE1CDK2CDK5GLSALDH1A1 | |
| SCHEMBL6250103 | 0.78 | CCNE1 (0.55) | CCNE1CDK2CDK5GLSCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4275759-A2 | QUINOLINE DERIVATIVES AS CHROMOBOX (CBX) PROTEIN INHIBITORS FOR TREATING CANCER | Dana-Farber Cancer Institute, Inc. (US) | 2023-11-15 | — | — | EP | disclosed |
| EP-3515449-B1 | QUINOLINE DERIVATIVES AS CHROMOBOX (CBX) PROTEIN INHIBITORS FOR TREATING CANCER | DANA FARBER CANCER INST INC (US) | 2023-07-12 | — | — | EP | disclosed |
| WO-2018058029-A1 | CHROMOBOX PROTEIN INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-03-29 | — | — | WO | disclosed |