Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20014606 | 0.80 | HTR2A (0.38) | RYR2HPGD | |
| SCHEMBL20014743 | 0.79 | HSD17B3 (0.40) | RYR2MEN1KMT2AALOX15TDP1 | |
| SCHEMBL20014517 | 0.79 | MEN1 (0.43) | RYR2MEN1KMT2AALOX15TDP1 | |
| SCHEMBL19329812 | 0.79 | TRPA1 (0.41) | TRPA1TDP1ALDH1A1HPGDGAA | |
| SCHEMBL20015243 | 0.79 | DRD2 (0.34) | RYR2MEN1KMT2AALOX15TDP1 | |
| SCHEMBL10906067 | 0.78 | — | — | |
| SCHEMBL20015049 | 0.77 | RYR2 (0.30) | RYR2 | |
| SCHEMBL20829466 | 0.76 | PRCP (0.41) | MEN1KMT2AALOX15TDP1ALDH1A1 | |
| SCHEMBL20123771 | 0.75 | TEAD1 (0.33) | RYR2MEN1KMT2AALOX15TDP1 | |
| SCHEMBL20123457 | 0.75 | DRD2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2620436-B1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | SHIONOGI & CO (JP) | 2018-05-09 | — | — | EP | disclosed |
| EP-2444400-B1 | SUBSTITUTED POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE | SHIONOGI & CO (JP) | 2018-03-28 | — | — | EP | disclosed |