Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.34 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6741597 | 0.77 | TGFBR1 (0.34) | DYRK1ATGFBR1CRHR1 | |
| SCHEMBL16848813 | 0.71 | DYRK1A (0.41) | DYRK1ATGFBR1SCN5APCSK9 | |
| SCHEMBL2750457 | 0.71 | TGFBR1 (0.51) | DYRK1ATGFBR1SCN5APCSK9 | |
| SCHEMBL6468289 | 0.70 | DYRK1A (0.44) | DYRK1ATGFBR1SCN5APCSK9 | |
| SCHEMBL21229247 | 0.70 | NTRK1 (0.36) | DYRK1ATGFBR1SCN5A | |
| SCHEMBL21286710 | 0.69 | TGFBR1 (0.32) | TGFBR1 | |
| SCHEMBL5872614 | 0.68 | KCNH2 (0.51) | DYRK1ATGFBR1SCN5ACNR1 | |
| SCHEMBL21017447 | 0.68 | PCSK9 (0.48) | DYRK1ATGFBR1SCN5APCSK9 | |
| SCHEMBL22763220 | 0.67 | DYRK1A (0.41) | DYRK1ATGFBR1SCN5APCSK9 | |
| SCHEMBL31069505 | 0.67 | DYRK1A (0.41) | DYRK1ATGFBR1SCN5APCSK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299372-A1 | INTERMEDIATE COMPOUNDS FOR THE PREPARATION OFSUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2018-03-28 | — | — | EP | disclosed |