Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.43 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23709136 | 0.92 | ALDH1A1 (0.50) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL8901601 | 0.85 | PDE4D (0.51) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL8903251 | 0.85 | PDE4D (0.51) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL8901597 | 0.85 | PDE4D (0.51) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL16613941 | 0.83 | PDE4D (0.34) | PDE4D | |
| SCHEMBL16613955 | 0.81 | TBXA2R (0.47) | ALDH1A1PDE4DPTGER2LMNATBXA2R | |
| SCHEMBL24092028 | 0.81 | ALDH1A1 (0.31) | ALDH1A1LMNA | |
| SCHEMBL7671306 | 0.80 | PDE4D (0.62) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL7671298 | 0.80 | PDE4D (0.62) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL7671311 | 0.80 | PDE4D (0.62) | ALDH1A1KDM4EHKDC1TDP1SAE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9931336-B2 | Combination therapy | AERIE PHARMACEUTICALS, INC. (US) | 2018-04-03 | — | — | US | disclosed |