Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.50 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.37 |
| ▸ | PTGFR | P43088 | 2/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.37 |
| ▸ | SLCO2A1 | Q92959 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20016613 | 0.92 | ALDH1A1 (0.43) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL16613955 | 0.90 | TBXA2R (0.47) | ALDH1A1PDE4DPTGER2TBXA2RLMNA | |
| SCHEMBL21924377 | 0.82 | ALDH1A1 (0.30) | ALDH1A1LMNA | |
| SCHEMBL21754428 | 0.81 | ALDH1A1 (0.63) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL18023365 | 0.81 | ALDH1A1 (0.41) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL2047469 | 0.79 | PDE4D (0.48) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL2047473 | 0.79 | PDE4D (0.48) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL2047465 | 0.79 | PDE4D (0.48) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL2047466 | 0.79 | PDE4D (0.48) | ALDH1A1KDM4EHKDC1TDP1SAE1 | |
| SCHEMBL11181706 | 0.78 | ALDH1A1 (0.52) | ALDH1A1KDM4EHKDC1TDP1SAE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210236477-A1 | COMBINATION THERAPY | ALCON INC. (CH) | 2021-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210236477-A1 | COMBINATION THERAPY | PTGS1, PTGS2, PTGIS | ALDH1A1 1638/4885KDM4E 4416/4885HKDC1 3422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.