Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.42 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3723996 | 0.77 | ROCK2 (0.45) | JAK2LRRK2ROCK2ROCK1PLK1 | |
| SCHEMBL27242853 | 0.76 | LRRK2 (0.56) | LRRK2KCNH2 | |
| SCHEMBL3656437 | 0.76 | MKNK2 (0.61) | ROCK2ROCK1 | |
| SCHEMBL23615978 | 0.75 | ROCK1 (0.49) | ROCK2ROCK1MYLK4 | |
| Hydrochloric Acid SCHEMBL612294 | 0.73 | IKBKB (0.56) | ROCK2ROCK1 | |
| SCHEMBL21857726 | 0.71 | KMT2A (0.66) | KDM4EALDH1A1GLAROCK2IKBKE | |
| SCHEMBL21359417 | 0.71 | MCL1 (0.47) | ROCK2ROCK1 | |
| SCHEMBL3721500 | 0.71 | PLK1 (0.52) | ROCK2ROCK1PLK1 | |
| SCHEMBL19029605 | 0.70 | ROCK2 (0.50) | KDM4EALDH1A1ROCK2ROCK1 | |
| SCHEMBL21359548 | 0.70 | ALK (0.56) | KDM4EROCK2ROCK1MYLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2934537-B1 | FACTOR IXA INHIBITORS | MERCK SHARP & DOHME (US) | 2018-04-04 | — | — | EP | disclosed |