Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.50 |
| ▸ | MELK | Q14680 | 1/20 | 0.48 |
| ▸ | ACLY | P53396 | 1/20 | 0.48 |
| ▸ | CTSV | O60911 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | NGLY1 | Q96IV0 | 1/20 | 0.48 |
| ▸ | FABP4 | P15090 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.46 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | AKT2 | P31751 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22861322 | 0.89 | MAPT (0.55) | ALKROCK2MELKMAPTROCK1 | |
| SCHEMBL31387882 | 0.84 | AKR1C3 (0.66) | AKR1C3AKR1C2CTSVCTSLMAPT | |
| SCHEMBL22861261 | 0.79 | AKT1 (0.56) | ROCK2MELKACLYROCK1MCL1 | |
| SCHEMBL21359592 | 0.78 | ACLY (0.53) | ALKROCK2MELKACLYROCK1 | |
| SCHEMBL21359390 | 0.77 | MIF (0.51) | ROCK2MELKACLYROCK1AKT1 | |
| SCHEMBL19029524 | 0.75 | GRIK1 (0.56) | ROCK2ACLYMAPTROCK1AKT1 | |
| SCHEMBL21359417 | 0.75 | MCL1 (0.47) | ROCK2ACLYROCK1MCL1AKT1 | |
| SCHEMBL21857726 | 0.75 | KMT2A (0.66) | ROCK2MELKACLYMAPTGFER | |
| SCHEMBL21359504 | 0.74 | ACMSD (0.54) | ROCK2ACLYROCK1AKT1AKT2 | |
| SCHEMBL21359560 | 0.73 | IDO1 (0.50) | ROCK2MELKACLYROCK1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230057076-A1 | Pyrazole-Containing Macrophage Migration Inhibitory Factor Inhibitors | UNIV YALE (US) | 2023-02-23 | — | — | US | disclosed |
| US-20210002264-A1 | Pyrazole-Containing Macrophage Migration Inhibitory Factor Inhibitors | UNIV YALE (US) | 2021-01-07 | — | — | US | disclosed |
| WO-2019178480-A1 | PYRAZOLE-CONTAINING MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS | YALE UNIVERSITY (US) | 2019-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210002264-A1 | Pyrazole-Containing Macrophage Migration Inhibitory Factor Inhibitors | MIF, MMP12, CSF1R | ALK 4572/4885ROCK2 1167/4885AKR1C3 1358/4885 |
| US-20230057076-A1 | Pyrazole-Containing Macrophage Migration Inhibitory Factor Inhibitors | MIF, MMP12, CSF1R | ALK 4684/4885ROCK2 1259/4885AKR1C3 1464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.