Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.58 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.58 |
| ▸ | CLK1 | P49759 | 2/20 | 0.58 |
| ▸ | STING1 | Q86WV6 | 7/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.53 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.36 |
| ▸ | SELE | P16581 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10221595 | 0.84 | GPR35 (0.63) | DYRK1ADYRK1BCLK1STING1HDAC3 | |
| SCHEMBL20026586 | 0.83 | HDAC3 (0.64) | DYRK1ADYRK1BCLK1STING1HDAC3 | |
| SCHEMBL12926164 | 0.81 | HDAC1 (0.78) | STING1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13556331 | 0.79 | HDAC1 (0.56) | STING1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6840172 | 0.77 | DYRK1A (0.69) | DYRK1ADYRK1BCLK1HDAC3HDAC4 | |
| SCHEMBL18177617 | 0.77 | CLK1 (0.59) | DYRK1ADYRK1BCLK1STING1HDAC3 | |
| SCHEMBL5999605 | 0.77 | DYRK1A (0.59) | DYRK1ADYRK1BCLK1HDAC3HDAC4 | |
| SCHEMBL9204578 | 0.76 | STING1 (0.63) | DYRK1ADYRK1BCLK1STING1HDAC3 | |
| SCHEMBL20022187 | 0.76 | STING1 (0.79) | STING1 | |
| SCHEMBL21234934 | 0.74 | CLK1 (0.51) | DYRK1ADYRK1BCLK1STING1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180093964-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180093964-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | STING1, IRF3, CGAS | DYRK1A 3459/4885DYRK1B 2866/4885CLK1 3775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.