Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.78 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.78 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.78 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.78 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.78 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.78 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.78 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.78 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.78 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.78 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.78 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10221595 | 0.81 | GPR35 (0.63) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL20022320 | 0.81 | DYRK1A (0.58) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL8213112 | 0.80 | HDAC1 (0.53) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL13556331 | 0.80 | HDAC1 (0.56) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL10052926 | 0.79 | HDAC1 (1.00) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL17149302 | 0.79 | HDAC1 (0.76) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL10400717 | 0.77 | HDAC1 (0.80) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL10400705 | 0.76 | HDAC1 (0.78) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL13036365 | 0.75 | HDAC2 (0.53) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL13556330 | 0.74 | CA12 (0.50) | HDAC1HDAC3HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872024-B2 | Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions | MERCK SHARP & DOHME CORP. (US) | 2011-01-18 | — | — | US | disclosed |
| US-7772238-B2 | Benzothiophene hydroxamic acid derivatives | MERCK SHARP & DOHME CORP. (US) | 2010-08-10 | — | — | US | disclosed |
| US-20090318541-A1 | Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions | MERCK SHARP & DOHME LLC | 2009-12-24 | — | — | US | disclosed |
| US-20090069391-A1 | Benzothiophene hydroxamic acid derivatives | MERCK SHARP & DOHME LLC | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318541-A1 | Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions | HDAC5, HAT1, BRDT | HDAC1 4/4885HDAC3 11/4885HDAC4 5/4885 |
| US-20090069391-A1 | Benzothiophene hydroxamic acid derivatives | BRDT, HDAC5, BRPF3 | HDAC1 4/4885HDAC3 8/4885HDAC4 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.