Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.66 |
| ▸ | SRC | P12931 | 7/20 | 0.66 |
| ▸ | KDR | P35968 | 6/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.66 |
| ▸ | RET | P07949 | 3/20 | 0.66 |
| ▸ | KIT | P10721 | 3/20 | 0.66 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.66 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.66 |
| ▸ | BRAF | P15056 | 2/20 | 0.66 |
| ▸ | FLT4 | P35916 | 2/20 | 0.66 |
| ▸ | CIT | O14578 | 2/20 | 0.66 |
| ▸ | GAK | O14976 | 2/20 | 0.66 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.66 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.66 |
| ▸ | STK17B | O94768 | 2/20 | 0.66 |
| ▸ | STK10 | O94804 | 2/20 | 0.66 |
| ▸ | ABL1 | P00519 | 2/20 | 0.66 |
| ▸ | LCK | P06239 | 2/20 | 0.66 |
| ▸ | LYN | P07948 | 2/20 | 0.66 |
| ▸ | MET | P08581 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17921472 | 0.91 | EGFR (0.71) | EGFRSRCKDRERBB2RET | |
| SCHEMBL10061876 | 0.90 | EGFR (0.78) | EGFRSRCKDRERBB2RET | |
| SCHEMBL16085087 | 0.90 | EGFR (0.68) | EGFRSRCKDRERBB2RET | |
| SCHEMBL799681 | 0.88 | EGFR (0.83) | EGFRSRCKDRERBB2RET | |
| SCHEMBL13319081 | 0.86 | EGFR (0.74) | EGFRSRCKDRERBB2RET | |
| SCHEMBL19885274 | 0.85 | EGFR (0.69) | EGFRSRCKDRERBB2RET | |
| SCHEMBL14286267 | 0.84 | EGFR (0.81) | EGFRSRCKDRERBB2RET | |
| SCHEMBL10102567 | 0.83 | EGFR (0.83) | EGFRSRCKDRERBB2RET | |
| SCHEMBL14191080 | 0.83 | EGFR (0.67) | EGFRSRCKDRERBB2RET | |
| SCHEMBL14190829 | 0.82 | EGFR (0.73) | EGFRSRCKDRERBB2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180094322-A1 | Biomarker for Predicting Colon Cancer Responsiveness to Anti-Tumor Treatment | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180094322-A1 | Biomarker for Predicting Colon Cancer Responsiveness to Anti-Tumor Treatment | EGFR, CBX2, CDYL2 | EGFR 1/4885SRC 184/4885KDR 423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.