Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.78 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.78 |
| ▸ | KIT | P10721 | 3/20 | 0.78 |
| ▸ | SRC | P12931 | 3/20 | 0.78 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.78 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.78 |
| ▸ | CIT | O14578 | 2/20 | 0.78 |
| ▸ | GAK | O14976 | 2/20 | 0.78 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.78 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.78 |
| ▸ | STK17B | O94768 | 2/20 | 0.78 |
| ▸ | STK10 | O94804 | 2/20 | 0.78 |
| ▸ | ABL1 | P00519 | 2/20 | 0.78 |
| ▸ | LCK | P06239 | 2/20 | 0.78 |
| ▸ | LYN | P07948 | 2/20 | 0.78 |
| ▸ | RET | P07949 | 2/20 | 0.78 |
| ▸ | MET | P08581 | 2/20 | 0.78 |
| ▸ | HCK | P08631 | 2/20 | 0.78 |
| ▸ | FGR | P09769 | 2/20 | 0.78 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14286267 | 0.92 | EGFR (0.81) | EGFRERBB2KITSRCERBB3 | |
| SCHEMBL28713534 | 0.92 | EGFR (0.92) | EGFRERBB2KITSRCERBB3 | |
| SCHEMBL29577833 | 0.92 | EGFR (0.92) | EGFRERBB2KITSRCERBB3 | |
| SCHEMBL31491119 | 0.91 | EGFR (0.85) | EGFRERBB2KITSRCERBB3 | |
| SCHEMBL20024367 | 0.90 | EGFR (0.66) | EGFRERBB2KITSRCERBB3 | |
| SCHEMBL19236250 | 0.90 | EGFR (0.80) | EGFRERBB2KITSRCERBB3 | |
| SCHEMBL29683371 | 0.90 | EGFR (0.80) | EGFRERBB2KITSRCERBB3 | |
| SCHEMBL31491114 | 0.89 | EGFR (0.87) | EGFRERBB2KITSRCERBB3 | |
| SCHEMBL19612073 | 0.88 | EGFR (0.86) | EGFRERBB2KITSRCERBB3 | |
| SCHEMBL21350019 | 0.88 | EGFR (0.80) | EGFRERBB2KITSRCERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10034851-B2 | Metal-salen complex compound, local anesthetic and antineoplastic drug | IHI CORPORATION (JP) | 2018-07-31 | — | — | US | disclosed |
| US-9895377-B2 | Solid forms of tyrosine kinase inhibitors, process for the preparation and their pharmaceutical composition thereof | LAURUS LABS LIMITED (IN) | 2018-02-20 | — | — | US | disclosed |
| US-20180008607-A1 | NOVEL EGFR MODULATORS AND USES THEREOF | ACEA BIOSCIENCES INC. (US) | 2018-01-11 | — | — | US | disclosed |
| US-9763949-B2 | EGFR modulators and uses thereof | ACEA BIOSCIENCES INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-20170224689-A1 | NOVEL PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF PROTEIN KINASES | ACEA BIOSCIENCES INC. (US) | 2017-08-10 | — | — | US | disclosed |
| US-9623027-B2 | — | — | 2017-04-18 | — | — | US | disclosed |
| US-9586965-B2 | Pyrrolo[2,3-d]pyrimidine compounds as inhibitors of protein kinases | ACEA BIOSCIENCES INC. (US) | 2017-03-07 | — | — | US | disclosed |
| US-9505732-B2 | Auto magnetic metal salen complex compound | IHI CORPORATION (JP) | 2016-11-29 | — | — | US | disclosed |
| US-20160263074-A1 | METAL-SALEN COMPLEX COMPOUND, LOCAL ANESTHETIC AND ANTINEOPLASTIC DRUG | ISHIKAWA YOSHIHIRO (JP) | 2016-09-15 | — | — | US | disclosed |
| US-20160208215-A1 | Generation of Endocrine Progenitor Cells from Human Pluripotent Stem Cells Using Small Molecules | TAKARA BIO EUROPE AB (SE) | 2016-07-21 | — | — | US | disclosed |
| US-20140206635-A1 | METAL-SALEN COMPLEX COMPOUND, LOCAL ANESTHETIC AND ANTINEOPLASTIC DRUG | IHI CORPORATION (JP) | 2014-07-24 | — | — | US | disclosed |
| US-20140046021-A1 | SELF-MAGNETIC METAL-SALEN COMPLEX COMPOUND | IHI CORPORATION (JP) | 2014-02-13 | — | — | US | disclosed |
| US-20140038940-A1 | NOVEL EGFR MODULATORS AND USES THEREOF | ACEA Therapeutics, Inc. | 2014-02-06 | — | — | US | disclosed |
| US-20140038981-A1 | NOVEL EGFR MODULATORS AND USES THEREOF | ACEA Therapeutics, Inc. | 2014-02-06 | — | — | US | disclosed |
| US-20140031352-A1 | SOLID FORMS OF TYROSINE KINASE INHIBITORS, PROCESS FOR THE PREPARATION AND THEIR PHARMACEUTICAL COMPOSITION THEREOF | LAURUS LABS PRIVATE LIMITED (IN) | 2014-01-30 | — | — | US | disclosed |
| US-20130287767-A1 | SUBSTITUTED 4-(ARYLAMINO) SELENOPHENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | KASINA LAILA INNOVA PHARMACEUTICALS PRIVATE LIMITED (IN) | 2013-10-31 | — | — | US | disclosed |
| US-20130266563-A1 | SUBSTITUTED 4-(SELENOPHEN-2(OR-3)-YLAMINO)PYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | KASINA LAILA INNOVA PHARMACEUTICALS PRIVATE LIMITED (IN) | 2013-10-10 | — | — | US | disclosed |
| US-20130096100-A1 | DI(ARYLAMINO)ARYL COMPOUND | ASTELLAS PHARMA INC. (JP) | 2013-04-18 | — | — | US | disclosed |
| US-20120029167-A1 | AUTO MAGNETIC METAL SALEN COMPLEX COMPOUND | YOSHIHIRO ISHIKAWA (JP) | 2012-02-02 | — | — | US | disclosed |
| US-20120029167-A1 | AUTO MAGNETIC METAL SALEN COMPLEX COMPOUND | YOSHIHIRO ISHIKAWA (JP) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096100-A1 | DI(ARYLAMINO)ARYL COMPOUND | ERBB4, EGFR, ALK | EGFR 2/4885ERBB2 6/4885KIT 684/4885 |
| US-20120029167-A1 | AUTO MAGNETIC METAL SALEN COMPLEX COMPOUND | SDHB, SDHA, SLC40A1 | EGFR 4323/4885ERBB2 3639/4885KIT 3533/4885 |
| US-20140031352-A1 | SOLID FORMS OF TYROSINE KINASE INHIBITORS, PROCESS FOR THE PREPARATION AND THEIR PHARMACEUTICAL COMPOSITION THEREOF | ABL1, SRC, TYRO3 | EGFR 88/4885ERBB2 8/4885KIT 362/4885 |
| US-20140038940-A1 | NOVEL EGFR MODULATORS AND USES THEREOF | EGFR, ERBB2, ERBB3 | EGFR 1/4885ERBB2 2/4885KIT 175/4885 |
| US-20140206635-A1 | METAL-SALEN COMPLEX COMPOUND, LOCAL ANESTHETIC AND ANTINEOPLASTIC DRUG | NCLN, KCNN2, NCSTN | EGFR 2282/4885ERBB2 1714/4885KIT 3791/4885 |
| US-20180008607-A1 | NOVEL EGFR MODULATORS AND USES THEREOF | EGFR, ERBB2, ERBB3 | EGFR 1/4885ERBB2 2/4885KIT 175/4885 |
| US-10034851-B2 | Metal-salen complex compound, local anesthetic and antineoplastic drug | NCLN, KCNN2, NCSTN | EGFR 2282/4885ERBB2 1714/4885KIT 3791/4885 |
| US-20170224689-A1 | NOVEL PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF PROTEIN KINASES | BMX, ITK, BLK | EGFR 64/4885ERBB2 16/4885KIT 410/4885 |
| US-20140046021-A1 | SELF-MAGNETIC METAL-SALEN COMPLEX COMPOUND | SSBP1, KCNN1, IMMT | EGFR 4330/4885ERBB2 4183/4885KIT 4701/4885 |
| US-20130266563-A1 | SUBSTITUTED 4-(SELENOPHEN-2(OR-3)-YLAMINO)PYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | RPS6, SULT1E1, SCLY | EGFR 319/4885ERBB2 258/4885KIT 1601/4885 |
| US-20130287767-A1 | SUBSTITUTED 4-(ARYLAMINO) SELENOPHENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | SELENOI, VHL, DPYD | EGFR 443/4885ERBB2 1100/4885KIT 1378/4885 |
| US-20160263074-A1 | METAL-SALEN COMPLEX COMPOUND, LOCAL ANESTHETIC AND ANTINEOPLASTIC DRUG | NCLN, KCNN2, NCSTN | EGFR 2282/4885ERBB2 1714/4885KIT 3791/4885 |
| US-20140038981-A1 | NOVEL EGFR MODULATORS AND USES THEREOF | EGFR, ERBB2, ERBB3 | EGFR 1/4885ERBB2 2/4885KIT 175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.