Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Toluene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.69 |
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | TSHR | P16473 | 2/20 | 0.69 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Toluene SCHEMBL27342895 | 1.00 | ACHE (0.69) | ACHELMNATSHRALOX12MEN1 | |
| Toluene SCHEMBL11136681 | 1.00 | ACHE (0.69) | ACHELMNATSHRALOX12MEN1 | |
| Toluene SCHEMBL22729215 | 1.00 | ACHE (0.69) | ACHELMNATSHRALOX12MEN1 | |
| Toluene SCHEMBL6443613 | 1.00 | ACHE (0.69) | ACHELMNATSHRALOX12MEN1 | |
| Toluene SCHEMBL5199381 | 1.00 | ACHE (0.69) | ACHELMNATSHRALOX12MEN1 | |
| Toluene SCHEMBL28769535 | 1.00 | ACHE (0.69) | ACHELMNATSHRALOX12MEN1 | |
| Toluene SCHEMBL5198578 | 1.00 | ACHE (0.69) | ACHELMNATSHRALOX12MEN1 | |
| Toluene SCHEMBL28873544 | 0.97 | LMNA (0.65) | ACHELMNATSHRALOX12MEN1 | |
| Toluene SCHEMBL3455878 | 0.97 | LMNA (0.65) | ACHELMNATSHRALOX12MEN1 | |
| Toluene SCHEMBL28323246 | 0.97 | LMNA (0.65) | ACHELMNATSHRALOX12MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3027 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122010847-A | Synthesis method of 1- [3, 5-bis (1-methylethyl) [1,1' -biphenyl ] -4-yl ] -2-bromo-1H-benzimidazole | 安徽大学 | 2026-05-12 | — | — | CN | claimed |
| EP-3383352-B1 | COMPOSITIONS FOR DENTAL VARNISHES AND METHODS OF MAKING AND USING SAME | COLGATE PALMOLIVE CO (US) | 2025-07-16 | — | — | EP | claimed |
| CN-119820927-A | Preparation method of elastic comfortable composite fabric | 南通和顺兴纺织集团有限公司 | 2025-04-15 | — | — | CN | claimed |
| CN-119775093-A | Anthracene-and pyrene-containing blue light material, preparation method and organic electroluminescent device | 吉林奥来德光电材料股份有限公司 | 2025-04-08 | — | — | CN | claimed |
| CN-119330919-A | Preparation method of 8-bromo-6-phenylnaphtho [2,1-b ] benzofuran | 中钢天源股份有限公司 | 2025-01-21 | — | — | CN | claimed |
| CN-221397765-U | Production line of liquid crystal monomer fluorine-containing propyl terphenyl butene | 江苏广域化学有限公司 | 2024-07-23 | — | — | CN | claimed |
| CN-118271265-A | Fluorescent main body material, preparation method and organic electroluminescent device comprising fluorescent main body material | 吉林奥来德光电材料股份有限公司 | 2024-07-02 | — | — | CN | claimed |
| CN-117603172-B | Main body material, preparation method thereof and organic electroluminescent device comprising main body material | 吉林奥来德光电材料股份有限公司 | 2024-04-30 | — | — | CN | claimed |
| CN-117920146-A | Ammonium sulfate production wastewater treatment agent and preparation method thereof | 太仓市业洪净水新材料有限公司 | 2024-04-26 | — | — | CN | claimed |
| US-20240117083-A1 | CHLOROPRENE POLYMER, CHLOROPRENE POLYMER LATEX, METHOD FOR PRODUCING CHLOROPRENE POLYMER LATEX, COMPOUND COMPOSITION AND VALCANIZATION MOLDED BODY | DENKA COMPANY LIMITED (JP) | 2024-04-11 | — | — | US | claimed |
| CN-1733930-A | Ergosterol preparation method | MENGYONG MEDICINE INDUSTRY COM (CN) | 2006-02-15 | — | — | CN | claimed |
| US-6100399-A | Synthesis for 4-aryl-5-pyrimidine imidazole substituted compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2000-08-08 | — | — | US | claimed |
| EP-1019393-A1 | NOVEL SYNTHESIS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-19 | — | — | EP | claimed |
| EP-1019393-A4 | NOVEL SYNTHESIS | SMITHKLINE BEECHAM CORP (US) | 2000-07-19 | — | — | EP | claimed |
| WO-1997023479-A1 | NOVEL SYNTHESIS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-03 | — | — | WO | claimed |
| EP-0265561-B1 | NOVEL CHITOSAN DERIVATIVE ITS PREPARATION AND POLYMER FILMS PRODUCED THEREFROM | NOVA CHEM LIMITED (CA) | 1989-04-26 | — | — | EP | claimed |
| EP-0265561-A1 | Novel chitosan derivative its preparation and polymer films produced therefrom | NOVA CHEM LIMITED (CA) | 1988-05-04 | — | — | EP | claimed |
| US-4619995-A | N,O-carboxymethyl chitosan and preparative method therefor | NOVA CHEM LIMITED (CA) | 1986-10-28 | — | — | US | claimed |
| US-4605581-A | IMPREGNATION WITH ORGANIC METALLIC COMPOUND AND RESIN, THEN CURING | GENERAL ELECTRIC COMPANY (US) | 1986-08-12 | — | — | US | claimed |
| EP-0071934-B1 | METHOD FOR PREPARING A COLOR STABLE CHROMOGENIC ANALYTICAL ELEMENT | MILES LABORATORIES, INC. (US) | 1986-06-11 | — | — | EP | claimed |