Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 3/20 | 0.42 |
| ▸ | DCAF1 | Q9Y4B6 | 2/20 | 0.39 |
| ▸ | HPGDS | O60760 | 3/20 | 0.39 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.38 |
| ▸ | FCER2 | P06734 | 2/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 2/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20028717 | 0.90 | DCAF1 (0.50) | PYGLDCAF1HPGDSPSMB5TACR3 | |
| SCHEMBL21854289 | 0.86 | CAPN1 (0.52) | CAPN1 | |
| SCHEMBL22886625 | 0.83 | PYGL (0.44) | PYGLDCAF1HPGDSCAPN1 | |
| SCHEMBL22886412 | 0.81 | PYGL (0.42) | PYGLHPGDSCAPN1CCR1 | |
| SCHEMBL22886627 | 0.81 | PYGL (0.48) | PYGLDCAF1PSMB5TACR3 | |
| SCHEMBL22886411 | 0.79 | PYGL (0.42) | PYGLDCAF1CAPN1PSMB5CCR1 | |
| SCHEMBL20028003 | 0.79 | CAPN1 (0.53) | CAPN1 | |
| SCHEMBL22897214 | 0.79 | DCAF1 (0.51) | PYGLDCAF1HPGDSKLKB1KLK1 | |
| SCHEMBL20027914 | 0.79 | DCAF1 (0.48) | PYGLDCAF1CAPN1 | |
| SCHEMBL22886634 | 0.78 | PYGL (0.41) | PYGLDCAF1CAPN1CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |