Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.54 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.45 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.42 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029141 | 0.88 | LPAR1 (0.62) | LPAR1LPAR3KDM4EMAPTLPAR2 | |
| SCHEMBL343051 | 0.81 | LPAR1 (0.56) | LPAR1LPAR3KDM4EMAPTLPAR2 | |
| SCHEMBL4035675 | 0.79 | MAPT (0.67) | LPAR1LPAR3KDM4EMAPTKMT2A | |
| SCHEMBL4034023 | 0.76 | LPAR1 (0.53) | LPAR1LPAR3KDM4EMAPTKMT2A | |
| SCHEMBL5529169 | 0.75 | MAPT (0.62) | LPAR1LPAR3KDM4EMAPTKMT2A | |
| SCHEMBL4033885 | 0.75 | LPAR1 (0.52) | LPAR1LPAR3KDM4EMAPTKMT2A | |
| SCHEMBL15897074 | 0.75 | LPAR1 (0.48) | LPAR1LPAR3KDM4EMAPTLPAR2 | |
| SCHEMBL343594 | 0.75 | LPAR1 (0.69) | LPAR1LPAR3KDM4EMAPTLPAR2 | |
| SCHEMBL4032711 | 0.74 | LPAR1 (0.48) | LPAR1LPAR3KDM4EMAPTLPAR2 | |
| SCHEMBL28398519 | 0.73 | LPAR1 (0.49) | LPAR1LPAR3KDM4EMAPTLPAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180093981-A1 | 2-Acylaminopropoanol-Type Glucosylceramide Synthase Inhibitors | GENZYME CORPORATION | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180093981-A1 | 2-Acylaminopropoanol-Type Glucosylceramide Synthase Inhibitors | ASAH2, GBA1, GAA | LPAR1 2360/4885LPAR3 3550/4885KDM4E 3499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.