SCHEMBL20030655

SCHEMBL20030655

Cc1cc2nc(-c3ccc4c(c3)c(C3CCN(C5CNC5)CC3)nn4C)sc2c(-c2ccc(Cl)cc2)c1CC(=O)O

nearest known ligand 0.36

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 16/20 0.36
PTGDR2 Q9Y5Y4 2/20 0.33
PDE5A O76074 1/20 0.32
PDE1A P54750 1/20 0.32
PDE1B Q01064 1/20 0.32
PDE4D Q08499 1/20 0.32
PDE7A Q13946 1/20 0.32
PDE1C Q14123 1/20 0.32
PDE3A Q14432 1/20 0.32
KDM4E B2RXH2 2/20 0.32
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20030967 0.92 CNR1 (0.37) CNR1PTGDR2PDE5APDE1APDE1B
SCHEMBL20030730 0.92 CNR1 (0.36) CNR1PTGDR2PDE5APDE1APDE1B
SCHEMBL20030418 0.91 CNR1 (0.39) CNR1PTGDR2PDE5APDE1APDE1B
SCHEMBL19906248 0.85 CNR1 (0.35) CNR1PTGDR2PDE5APDE1APDE1B
SCHEMBL20030905 0.85 KDM4E (0.35) CNR1PTGDR2PDE5APDE1APDE1B
SCHEMBL19906080 0.85 CNR1 (0.35) CNR1PTGDR2PDE5APDE1APDE1B
SCHEMBL20030662 0.84 CYP3A4 (0.36) CNR1
SCHEMBL22506332 0.84 CYP3A4 (0.36) CNR1
SCHEMBL20030823 0.84 CNR1 (0.43) CNR1
SCHEMBL20030417 0.84 P2RX3 (0.36) CNR1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018064080-A1 BENZOTHIAZOL-6-YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING HIV INFECTION GILEAD SCIENCES, INC. (US) 2018-04-05 WO disclosed