Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30020309 | 0.83 | NOTUM (0.51) | RAB9ANPC1NOTUMPOLBLMNA | |
| SCHEMBL28440906 | 0.81 | MAPT (0.52) | RAB9ANPC1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL9199765 | 0.81 | RAB9A (0.57) | RAB9ANPC1NOTUMLMNAMAPT | |
| SCHEMBL20031383 | 0.81 | NOTUM (0.56) | RAB9ANPC1NOTUMMAPTSMN1; SMN2 | |
| SCHEMBL22504981 | 0.79 | KMT2A (0.59) | RAB9ANPC1POLBLMNAMAPT | |
| SCHEMBL4684431 | 0.79 | MAPT (0.57) | RAB9ANPC1LMNAMAPTCYP1A2 | |
| SCHEMBL2609422 | 0.78 | RAB9A (0.53) | RAB9ANPC1NOTUMPOLBLMNA | |
| SCHEMBL2301990 | 0.77 | RAB9A (0.57) | RAB9ANPC1NOTUMPOLBLMNA | |
| SCHEMBL9213944 | 0.76 | RAB9A (0.59) | RAB9ANPC1NOTUMPOLBLMNA | |
| SCHEMBL14452037 | 0.76 | POLB (0.68) | RAB9ANPC1NOTUMPOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3519385-B1 | CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LTD (GB) | 2020-11-18 | — | — | EP | disclosed |
| WO-2018060689-A1 | CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LIMITED (GB) | 2018-04-05 | — | — | WO | disclosed |
| CN-101817799-B | Cyanoacrylate compound and application thereof in pesticide and medicine | UNIV NANKAI | 2013-08-21 | — | — | CN | disclosed |
| CN-101817799-A | Cyanoacrylate compound and application thereof in pesticide and medicine | UNIV NANKAI | 2010-09-01 | — | — | CN | disclosed |