Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20031207 | 0.81 | RAB9A (0.53) | NOTUMNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL9199765 | 0.80 | RAB9A (0.57) | NOTUMNPC1RAB9AMAPTTP53 | |
| SCHEMBL10257193 | 0.80 | NOTUM (0.56) | NOTUMNPC1RAB9AUSP30MAPT | |
| SCHEMBL7372548 | 0.80 | RORC (0.41) | NOTUMNPC1RAB9AMAPTMAPK1 | |
| SCHEMBL19522443 | 0.79 | NPC1 (0.70) | NOTUMNPC1RAB9AMAPTMAPK1 | |
| SCHEMBL9209121 | 0.79 | NOTUM (0.63) | NOTUMNPC1RAB9AMAPTTP53 | |
| SCHEMBL1544440 | 0.78 | NOTUM (0.54) | NOTUMNPC1RAB9AUSP30MAPT | |
| SCHEMBL20031386 | 0.78 | SMN1; SMN2 (0.58) | NPC1RAB9AUSP30MAPTMAPK1 | |
| SCHEMBL23221331 | 0.76 | NPC1 (0.51) | NOTUMNPC1RAB9AUSP30SMN1; SMN2 | |
| SCHEMBL19017804 | 0.76 | MAPT (0.55) | NOTUMNPC1RAB9AUSP30MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3519385-B1 | CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LTD (GB) | 2020-11-18 | — | — | EP | disclosed |
| WO-2018060689-A1 | CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LIMITED (GB) | 2018-04-05 | — | — | WO | disclosed |