Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 15/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | BRD2 | P25440 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TAF1 | P21675 | 1/20 | 0.40 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21033158 | 0.76 | BRD4 (0.50) | USP30BRD4BRD2 | |
| SCHEMBL30845795 | 0.75 | TGFBR1 (0.48) | USP30BRD4BRD2 | |
| SCHEMBL21033470 | 0.73 | KDM4E (0.53) | USP30BRD4CYP1A2BRD2ALDH1A1 | |
| SCHEMBL24834491 | 0.72 | NPC1 (0.52) | HSD17B10MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL17632872 | 0.72 | USP30 (0.77) | USP30 | |
| SCHEMBL17632871 | 0.72 | USP30 (0.77) | USP30 | |
| Hydrochloric Acid SCHEMBL28842904 | 0.71 | NPC1 (0.50) | HSD17B10MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL8300240 | 0.69 | BRD4 (0.70) | BRD4BRD2NR3C1PGR | |
| SCHEMBL24305069 | 0.68 | MAP4K1 (0.57) | — | |
| SCHEMBL24305248 | 0.68 | MAP4K1 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018060689-A1 | CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LIMITED (GB) | 2018-04-05 | — | — | WO | disclosed |