Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 7/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20609148 | 1.00 | APP (0.41) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21374330 | 1.00 | APP (0.41) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL20609147 | 1.00 | APP (0.41) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28433668 | 1.00 | APP (0.41) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL18970854 | 1.00 | APP (0.41) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23902364 | 1.00 | APP (0.41) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL20159697 | 0.91 | APP (0.38) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23923654 | 0.82 | PSEN1 (0.41) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23923655 | 0.82 | PSEN1 (0.41) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22111574 | 0.82 | PSEN1 (0.41) | APPPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020120521-A1 | 7-PHENOXY-N-(3-AZABICYCLO[3.2.1]OCTAN-8-YL)-6,7-DIHYDRO-5H-PYRROLO[1,2-B][1,2,4]TRIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS GAMMA-SECRETASE MODULATORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2020-06-18 | — | — | WO | disclosed |
| WO-2018060300-A1 | BRIDGED PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2018-04-05 | — | — | WO | disclosed |