Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 7/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20609148 | 0.91 | APP (0.41) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL18970854 | 0.91 | APP (0.41) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL28433668 | 0.91 | APP (0.41) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL20031799 | 0.91 | APP (0.41) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL20609147 | 0.91 | APP (0.41) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23902364 | 0.91 | APP (0.41) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21374330 | 0.91 | APP (0.41) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23504757 | 0.81 | APP (0.33) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23504818 | 0.80 | CHRNA3 (0.36) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23504807 | 0.80 | CHRNB2 (0.39) | APPCHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018087018-A1 | PHENOXYTRIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2018-05-17 | — | — | WO | disclosed |