Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18713812 | 0.84 | ALDH1A1 (0.35) | LMNAHTTTP53MEN1KMT2A | |
| SCHEMBL21508008 | 0.83 | RXRA (0.39) | — | |
| SCHEMBL20032330 | 0.82 | KCNH2 (0.35) | LMNAHTTTP53MEN1KMT2A | |
| SCHEMBL21508393 | 0.81 | KCNH2 (0.38) | LMNAHTTTP53GABRA1GABRB1 | |
| SCHEMBL20032158 | 0.81 | CNR1 (0.42) | LMNAHTTTP53HPGDTRPA1 | |
| SCHEMBL21507795 | 0.79 | CHRM1 (0.41) | LMNAHTTTP53GABRA1GABRB1 | |
| SCHEMBL16574097 | 0.78 | IDO1 (0.42) | CHRM1ADORA2AADORA1JAK2 | |
| SCHEMBL21508077 | 0.77 | KCNH2 (0.40) | LMNAHTTTP53GABRA1GABRB1 | |
| SCHEMBL21507956 | 0.77 | PTGDR2 (0.41) | LMNAHTTTP53MEN1KMT2A | |
| SCHEMBL21507825 | 0.76 | HTR2A (0.41) | LMNAHTTTP53TRPV1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018060949-A1 | TRYPTOPHAN HYDROXYLASE INHIBITORS FOR USE IN THE TREATMENT OF LIVER DISEASES | ROIVANT SCIENCES GMBH (CH) | 2018-04-05 | — | — | WO | disclosed |