Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1763294 | 0.78 | LMNA (0.46) | LMNATSHRGSK3BHDAC6ALDH1A1 | |
| SCHEMBL2145369 | 0.78 | LMNA (0.48) | LMNATSHRGSK3BHDAC6ALDH1A1 | |
| SCHEMBL17446874 | 0.77 | LMNA (0.44) | LMNATSHRGSK3BHDAC6ALDH1A1 | |
| SCHEMBL20239585 | 0.77 | GSK3B (0.43) | LMNATSHRGSK3BHDAC6ALDH1A1 | |
| SCHEMBL11450476 | 0.76 | LMNA (0.47) | LMNATSHRGSK3BHDAC6ALDH1A1 | |
| SCHEMBL3411329 | 0.74 | LMNA (0.46) | LMNATSHRGSK3BHDAC6ALDH1A1 | |
| SCHEMBL14997447 | 0.74 | LMNA (0.46) | LMNATSHRGSK3BHDAC6ALDH1A1 | |
| SCHEMBL2872059 | 0.73 | GSK3B (0.67) | LMNATSHRGSK3BHDAC6ALDH1A1 | |
| SCHEMBL13665361 | 0.73 | LMNA (0.44) | LMNATSHRGSK3BHDAC6ALDH1A1 | |
| SCHEMBL27261318 | 0.73 | LMNA (0.44) | LMNATSHRGSK3BHDAC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938258-B2 | Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof | Karyopharm Therapeutics Inc. (US) | 2018-04-10 | — | — | US | disclosed |