Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30765381 | 0.85 | L3MBTL1 (0.55) | L3MBTL1KDM4EHPGDRAB9AMEN1 | |
| SCHEMBL15551701 | 0.85 | L3MBTL1 (0.55) | L3MBTL1KDM4EHPGDRAB9AMEN1 | |
| SCHEMBL16687456 | 0.75 | HPGD (0.55) | L3MBTL1HPGDRAB9AMEN1KMT2A | |
| SCHEMBL13336459 | 0.75 | HPGD (0.51) | L3MBTL1HPGDRAB9AMEN1KMT2A | |
| SCHEMBL10720509 | 0.75 | L3MBTL1 (0.71) | L3MBTL1KDM4EHPGDRAB9AMEN1 | |
| SCHEMBL18274825 | 0.74 | HPGD (0.56) | HPGDRAB9AMEN1KMT2ATSHR | |
| SCHEMBL15551438 | 0.74 | HPGD (0.56) | HPGDRAB9AMEN1KMT2ATSHR | |
| SCHEMBL585882 | 0.73 | HPGD (0.49) | L3MBTL1HPGDMEN1KMT2ATSHR | |
| SCHEMBL29709543 | 0.73 | HPGD (0.49) | L3MBTL1HPGDMEN1KMT2ATSHR | |
| SCHEMBL15538911 | 0.72 | HPGD (0.46) | L3MBTL1KDM4EHPGDRAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938258-B2 | Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof | Karyopharm Therapeutics Inc. (US) | 2018-04-10 | — | — | US | disclosed |