SCHEMBL2003395

SCHEMBL2003395

CO[Si](OC)(c1ccc(CCl)cc1)c1ccc(CCl)cc1

nearest known ligand 0.34

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.34
CA2 P00918 2/20 0.34
TTR P02766 2/20 0.33
RAB9A P51151 2/20 0.32
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
NPC1 O15118 1/20 0.30
POLB P06746 1/20 0.30
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL137014 0.82 CA1 (0.34) CA1CA2TTR
SCHEMBL15453502 0.80 CA1 (0.33) CA1CA2TTR
SCHEMBL25367782 0.80 TTR (0.36) CA1CA2TTR
SCHEMBL1562733 0.79 TP53 (0.40) CA2RAB9AALDH1A1TDP1NPC1
SCHEMBL17191690 0.77 CA1 (0.31) CA1CA2TTR
SCHEMBL12567428 0.77 CA1 (0.31) CA1CA2TTR
SCHEMBL3470794 0.73 CA1 (0.38) CA1CA2GAA
SCHEMBL15444222 0.73 CA1 (0.34) CA1CA2TTR
SCHEMBL3482008 0.72 TP53 (0.50) RAB9AKDM4EALDH1A1NPC1POLB
SCHEMBL4848752 0.71 CA1 (0.37) CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1445288-B1 Organic-inorganic composite particle and process for preparation thereof ROHM & HAAS (US) 2017-03-08 EP disclosed
US-8906982-B2 Coating with improved hiding compositions prepared therewith, and processes for the preparation thereof ROHM AND HAAS COMPANY (US) 2014-12-09 US disclosed
US-8822569-B2 Composite particles ROHM AND HAAS COMPANY (US) 2014-09-02 US disclosed
US-7960026-B2 Organic-inorganic composite particle and process for preparation thereof ROHM AND HAAS COMPANY (US) 2011-06-14 US disclosed
EP-2050796-B1 Coating with improved hiding, compositions prepared therewith, and processes for the preparation thereof ROHM & HAAS (US) 2010-09-22 EP disclosed
US-20090306278-A1 Coating with improved hiding compositions prepared therewith, and processes for the preparation thereof ROHM AND HAAS COMPANY 2009-12-10 US disclosed
EP-2050796-A1 Coating with improved hiding, compositions prepared therewith, and processes for the preparation thereof Rohm and Haas Company (US) 2009-04-22 EP disclosed
US-7488534-B2 Organic-inorganic composite particle and process for preparation thereof ROHM AND HAAS COMPANY (US) 2009-02-10 US disclosed
US-20090017304-A1 Organic-inorganic composite particle and process for preparation thereof KOLLER ANNE DENISE 2009-01-15 US disclosed
EP-1398333-B1 Polymer particles having select pendant groups and composition prepared therefrom ROHM & HAAS (US) 2008-07-09 EP disclosed
US-20060223911-A1 Composite particles ROHM AND HAAS COMPANY 2006-10-05 US disclosed
US-7081488-B2 Coating with improved hiding, compositions prepared therewith, and processes for the preparation thereof ROHM AND HAAS COMPANY (US) 2006-07-25 US disclosed
US-20050009954-A1 Aqueous polymer composition ROHM AND HAAS COMPANY 2005-01-13 US disclosed
EP-1496091-A1 Aqueous polymer composition ROHM AND HAAS COMPANY (US) 2005-01-12 EP disclosed
EP-1445288-A2 Organic-inorganic composite particle and process for preparation thereof ROHM AND HAAS COMPANY (US) 2004-08-11 EP disclosed
US-20040151910-A1 Organic-inorganic composite particle and process for preparation thereof ROHM AND HAAS COMPANY 2004-08-05 US disclosed
US-20040054063-A1 Polymer particles having select pendant groups and composition prepared therefrom ROHM AND HAAS COMPANY 2004-03-18 US disclosed
EP-1398333-A1 Polymer particles having select pendant groups and composition prepared therefrom ROHM AND HAAS COMPANY (US) 2004-03-17 EP disclosed
US-20030018103-A1 Coating with improved hiding, compositions prepared therewith, and processes for the preparation thereof ROHM AND HAAS COMPANY 2003-01-23 US disclosed
EP-1273636-A2 Coating with improved hiding compositions prepared therewith, and processes for the preparation thereof ROHM AND HAAS COMPANY (US) 2003-01-08 EP disclosed