Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ULK1 | O75385 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 6/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | NRAS | P01111 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18918820 | 0.81 | ULK1 (0.46) | BRD4ULK1KITPIK3CGSLC6A2 | |
| SCHEMBL18918838 | 0.74 | ULK1 (0.51) | BRD4ULK1KITPIK3CGRIPK1 | |
| SCHEMBL20034104 | 0.73 | BRD4 (0.41) | BRD4ULK1KITPIK3CGCCNB2 | |
| SCHEMBL20034116 | 0.73 | BRD4 (0.41) | BRD4ULK1KITPIK3CGCCNB2 | |
| SCHEMBL20034085 | 0.73 | BRD4 (0.45) | BRD4ULK1KITPIK3CGCCNB2 | |
| SCHEMBL18918839 | 0.72 | ULK1 (0.51) | BRD4ULK1KITRIPK1 | |
| SCHEMBL20034086 | 0.72 | BRD4 (0.40) | BRD4ULK1KITPIK3CGCCNB2 | |
| SCHEMBL20034101 | 0.72 | BRD4 (0.41) | BRD4ULK1KITPIK3CGKCNH2 | |
| SCHEMBL20034134 | 0.72 | BRD4 (0.41) | BRD4ULK1KITPIK3CGKCNH2 | |
| SCHEMBL20034117 | 0.71 | BRD4 (0.39) | BRD4ULK1KITPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938273-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2018-04-10 | — | — | US | disclosed |