SCHEMBL20035360

SCHEMBL20035360

Cc1nc(-c2ccc3ccccc3c2)nc2c1oc1ccccc12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.47
ALDH1A1 P00352 5/20 0.46
KDM4E B2RXH2 3/20 0.46
KMT2A Q03164 2/20 0.46
MEN1 O00255 1/20 0.46
NPC1 O15118 1/20 0.45
CYP1A2 P05177 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP2C19 P33261 1/20 0.45
RAB9A P51151 1/20 0.45
MAPT P10636 8/20 0.43
LMNA P02545 7/20 0.43
POLB P06746 2/20 0.43
USP2 O75604 2/20 0.43
HSD17B10 Q99714 2/20 0.43
HTT P42858 1/20 0.43
HPGD P15428 2/20 0.42
MAPK1 P28482 2/20 0.41
HRH4 Q9H3N8 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19169662 0.85 TSHR (0.60) TSHRALDH1A1KDM4EKMT2AMEN1
SCHEMBL16919856 0.84 TSHR (0.62) TSHRALDH1A1KDM4EKMT2AMEN1
SCHEMBL16902206 0.84 MAPT (0.48) TSHRALDH1A1KDM4EKMT2AMEN1
SCHEMBL19320199 0.84 SMN1; SMN2 (0.49) TSHRALDH1A1KDM4EKMT2AMEN1
SCHEMBL19162674 0.83 MAPT (0.43) TSHRALDH1A1KDM4EKMT2AMEN1
SCHEMBL16902207 0.81 TSHR (0.46) TSHRALDH1A1KDM4EKMT2AMEN1
SCHEMBL19169805 0.81 LMNA (0.50) TSHRALDH1A1KDM4EKMT2AMEN1
SCHEMBL16902200 0.81 MAPT (0.46) TSHRALDH1A1KDM4EKMT2AMEN1
SCHEMBL16902178 0.81 MAPT (0.46) TSHRALDH1A1KDM4EKMT2AMEN1
SCHEMBL16902179 0.80 MAPT (0.45) TSHRALDH1A1KDM4EKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3305792-A1 NITROGEN-CONTAINING CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT EMITTING ELEMENT USING SAME LG Chem, Ltd. (KR) 2018-04-11 EP disclosed