Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6475010 | 0.83 | ALDH1A1 (0.60) | ALDH1A1KDM4EPOLBCYP2A13MEN1 | |
| SCHEMBL3198447 | 0.78 | ALDH1A1 (0.74) | ALDH1A1KDM4EMEN1KMT2AFAAH | |
| SCHEMBL18753626 | 0.77 | KDM4E (0.70) | ALDH1A1KDM4EPOLBCYP2A13RAB9A | |
| SCHEMBL2107499 | 0.75 | ALDH1A1 (0.96) | ALDH1A1KDM4EPOLBCYP2A13MEN1 | |
| SCHEMBL20964522 | 0.74 | ALDH1A1 (0.46) | ALDH1A1POLBMEN1KMT2AMTNR1B | |
| SCHEMBL18753881 | 0.74 | ALDH1A1 (0.55) | ALDH1A1KDM4EPOLBMEN1KMT2A | |
| SCHEMBL5743019 | 0.74 | CCR3 (0.55) | ALDH1A1KDM4EPOLBCYP2A13CXCR4 | |
| SCHEMBL29941203 | 0.74 | ALDH1A1 (1.00) | ALDH1A1KDM4EPOLBCYP2A13RAB9A | |
| SCHEMBL29087431 | 0.74 | KDM4E (0.64) | ALDH1A1KDM4EPOLBCYP2A13MEN1 | |
| SCHEMBL4036908 | 0.73 | ALDH1A1 (0.68) | ALDH1A1KDM4EPOLBCYP2A13MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2704721-B1 | PYRUVATE KINASE ACTIVATORS FOR USE IN THERAPY | AGIOS PHARMACEUTICALS INC (US) | 2018-04-11 | — | — | EP | disclosed |