Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17001569 | 0.84 | P2RX7 (0.44) | ALDH1A1SMN1; SMN2ACHEL3MBTL1MEN1 | |
| SCHEMBL16995081 | 0.83 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2ACHEL3MBTL1MEN1 | |
| SCHEMBL19940615 | 0.81 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2ACHEL3MBTL1MEN1 | |
| SCHEMBL16995086 | 0.72 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2ACHEL3MBTL1MEN1 | |
| SCHEMBL18274483 | 0.71 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2ACHEL3MBTL1MEN1 | |
| SCHEMBL2781959 | 0.71 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2ACHEL3MBTL1MEN1 | |
| SCHEMBL15797646 | 0.71 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2ACHEL3MBTL1MEN1 | |
| SCHEMBL18371700 | 0.69 | P2RX7 (0.46) | P2RX7 | |
| SCHEMBL2784285 | 0.68 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2ACHEL3MBTL1MEN1 | |
| SCHEMBL18274491 | 0.68 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2ACHEL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3102573-B1 | SUBSTITUTED THIAZOLE OR OXAZOLE P2X7 RECEPTOR ANTAGONISTS | AXXAM SPA (IT) | 2018-04-11 | — | — | EP | disclosed |