SCHEMBL20037041

SCHEMBL20037041

Cc1ccc(-n2nc(C)c(N)c2C)cc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 7/20 0.72
RAB9A P51151 6/20 0.51
NPC1 O15118 5/20 0.51
MAPT P10636 5/20 0.51
TP53 P04637 2/20 0.51
MEN1 O00255 2/20 0.51
KMT2A Q03164 2/20 0.51
CYP1A2 P05177 1/20 0.51
CYP3A4 P08684 1/20 0.51
CYP2C9 P11712 1/20 0.51
CYP2C19 P33261 1/20 0.51
LMNA P02545 4/20 0.47
L3MBTL1 Q9Y468 4/20 0.47
TSHR P16473 2/20 0.47
ALDH1A1 P00352 4/20 0.46
HTT P42858 2/20 0.46
PRNP P04156 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
RXFP1 Q9HBX9 1/20 0.44
STAT1 P42224 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL11654225 0.98 SMN1; SMN2 (0.70) SMN1; SMN2RAB9ANPC1MAPTTP53
SCHEMBL11652228 0.85 SMN1; SMN2 (0.68) SMN1; SMN2RAB9ANPC1MEN1KMT2A
SCHEMBL6966371 0.84 SMN1; SMN2 (1.00) SMN1; SMN2RAB9ANPC1MAPTMEN1
SCHEMBL16486063 0.84 ALDH1A1 (0.54) SMN1; SMN2RAB9ANPC1MAPTTP53
Water SCHEMBL11653913 0.83 SMN1; SMN2 (0.66) SMN1; SMN2RAB9ANPC1MAPTMEN1
Water SCHEMBL11652814 0.82 SMN1; SMN2 (0.96) SMN1; SMN2RAB9ANPC1MAPTMEN1
SCHEMBL17610399 0.82 SMN1; SMN2 (0.64) SMN1; SMN2RAB9ANPC1MAPTTP53
SCHEMBL20037151 0.80 SMN1; SMN2 (0.62) SMN1; SMN2RAB9AMAPTCYP2C9L3MBTL1
SCHEMBL20037190 0.80 SMN1; SMN2 (0.62) SMN1; SMN2MAPTALDH1A1PDE4D
SCHEMBL23558008 0.80 SMN1; SMN2 (0.61) SMN1; SMN2RAB9ANPC1MAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021123294-A1 OGA INHIBITOR COMPOUNDS JANSSEN PHARMACEUTICA NV (BE) 2021-06-24 WO disclosed
WO-2018065607-A1 CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN RELATED PEPTIDASE 6 (KLK6) Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) 2018-04-12 WO disclosed
EP-3305781-A1 CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN-RELATED PEPTIDASE 6 (KLK6) Deutsches Krebsforschungszentrum (DE) 2018-04-11 EP disclosed