Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK6 | Q92876 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | SLC34A1 | Q06495 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20037138 | 0.87 | LMNA (0.68) | KLK6LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL20037206 | 0.84 | ALDH1A1 (0.57) | KLK6LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL20037047 | 0.84 | KLK6 (0.74) | KLK6LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL20037169 | 0.82 | KLK6 (0.81) | KLK6RAB9APRSS1PRSS2PRSS3 | |
| SCHEMBL20037114 | 0.82 | KLK6 (0.55) | KLK6LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL20037080 | 0.79 | KLK6 (0.82) | KLK6LMNARAB9AKDM4EMEN1 | |
| SCHEMBL20037154 | 0.78 | KLK6 (0.59) | KLK6LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL20037230 | 0.76 | KLK6 (0.76) | KLK6RAB9APRSS1PRSS2PRSS3 | |
| SCHEMBL20075148 | 0.75 | SLC34A1 (0.53) | LMNAALDH1A1HTTSMN1; SMN2RAB9A | |
| SCHEMBL324309 | 0.75 | ALDH1A1 (0.65) | LMNAALDH1A1HTTSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018065607-A1 | CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN RELATED PEPTIDASE 6 (KLK6) | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2018-04-12 | — | — | WO | disclosed |
| EP-3305781-A1 | CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN-RELATED PEPTIDASE 6 (KLK6) | Deutsches Krebsforschungszentrum (DE) | 2018-04-11 | — | — | EP | disclosed |