Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006741 | 0.92 | LMNA (0.54) | LMNAALDH1A1SMN1; SMN2MAPTAHR | |
| SCHEMBL2006991 | 0.91 | LMNA (0.47) | LMNAALDH1A1SMN1; SMN2MAPTAHR | |
| SCHEMBL2008723 | 0.87 | LMNA (0.49) | LMNAALDH1A1SMN1; SMN2MAPTAHR | |
| SCHEMBL2004312 | 0.86 | LMNA (0.46) | LMNAALDH1A1SMN1; SMN2MAPTAHR | |
| SCHEMBL2003054 | 0.86 | LMNA (0.51) | LMNAALDH1A1SMN1; SMN2MAPTAHR | |
| SCHEMBL2007318 | 0.85 | LMNA (0.47) | LMNAALDH1A1SMN1; SMN2MAPTAHR | |
| SCHEMBL4083410 | 0.85 | PDE4A (0.47) | LMNAALDH1A1SMN1; SMN2MAPTSERPINE1 | |
| SCHEMBL2002672 | 0.85 | LMNA (0.48) | LMNAALDH1A1SMN1; SMN2MAPTAHR | |
| SCHEMBL2000164 | 0.84 | AHR (0.50) | LMNAALDH1A1SMN1; SMN2MAPTAHR | |
| SCHEMBL2006000 | 0.84 | LMNA (0.48) | LMNAALDH1A1SMN1; SMN2MAPTAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |