Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006741 | 0.92 | LMNA (0.54) | LMNASMN1; SMN2ALDH1A1MAPTHDAC1 | |
| SCHEMBL2003729 | 0.91 | LMNA (0.47) | LMNASMN1; SMN2ALDH1A1MAPTHDAC1 | |
| SCHEMBL2003054 | 0.87 | LMNA (0.51) | LMNASMN1; SMN2ALDH1A1MAPTHDAC1 | |
| SCHEMBL2003112 | 0.85 | LMNA (0.49) | LMNASMN1; SMN2ALDH1A1MAPTHDAC1 | |
| SCHEMBL2001838 | 0.85 | LMNA (0.47) | LMNASMN1; SMN2ALDH1A1MAPTHDAC1 | |
| SCHEMBL4098078 | 0.85 | TUBB4A (0.51) | LMNASMN1; SMN2ALDH1A1MAPTHDAC1 | |
| SCHEMBL2006480 | 0.84 | LMNA (0.48) | LMNASMN1; SMN2ALDH1A1MAPTHDAC1 | |
| SCHEMBL2008365 | 0.84 | AHR (0.51) | LMNASMN1; SMN2ALDH1A1MAPTHDAC1 | |
| SCHEMBL2003245 | 0.83 | LMNA (0.47) | LMNASMN1; SMN2ALDH1A1MAPTHDAC1 | |
| SCHEMBL2005660 | 0.82 | ALDH1A1 (0.51) | LMNAALDH1A1MAPTKDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |