Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.50 |
| ▸ | MTOR | P42345 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | GABRE | P78334 | 1/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.40 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18291193 | 0.84 | KMT2A (0.44) | PIK3CAMTORKMT2AMEN1ATM | |
| SCHEMBL20249334 | 0.83 | PPARD (0.45) | PIK3CAMTORKMT2AMEN1ATM | |
| SCHEMBL20038290 | 0.83 | KMT2A (0.43) | PIK3CAMTORKMT2AMEN1ATM | |
| SCHEMBL18291697 | 0.82 | MAP3K11 (0.39) | PIK3CAMTORKMT2AMEN1ATM | |
| SCHEMBL18291692 | 0.81 | PIK3CA (0.47) | PIK3CAMTORKMT2AMEN1ATM | |
| SCHEMBL1126048 | 0.80 | ALDH1A1 (0.54) | KMT2AMEN1ATMGABRPGABRD | |
| SCHEMBL609436 | 0.80 | LMNA (0.62) | KMT2AMEN1ATMLMNAHRH3 | |
| Hydrochloric Acid SCHEMBL1126084 | 0.79 | ALDH1A1 (0.53) | KMT2AMEN1ATMGABRPGABRD | |
| SCHEMBL14212807 | 0.79 | LMNA (0.57) | KMT2AMEN1ATMLMNAHRH3 | |
| Hydrochloric Acid SCHEMBL1126132 | 0.79 | LMNA (0.60) | KMT2AMEN1ATMLMNAHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |