Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 9/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | NEK2 | P51955 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22629266 | 0.83 | HRH3 (0.58) | NOTUMKDM4ECYP2C19USP2HPGD | |
| SCHEMBL237457 | 0.81 | KDM4E (0.55) | NOTUMKDM4ECYP2C19USP2HPGD | |
| SCHEMBL20037680 | 0.77 | NOTUM (0.50) | NOTUMKDM4ECYP2C19USP2HPGD | |
| SCHEMBL16398202 | 0.77 | NEK2 (0.52) | NOTUMKDM4ECYP2C19USP2HPGD | |
| SCHEMBL20207616 | 0.77 | HDAC3 (0.46) | KDM4ECYP2C19 | |
| SCHEMBL23114831 | 0.77 | PRMT5 (0.47) | NOTUMKDM4ECYP2C19USP2HPGD | |
| SCHEMBL1441410 | 0.77 | CHRNB2 (0.54) | NOTUMKDM4ECYP2C19USP2HPGD | |
| SCHEMBL20249117 | 0.77 | HRH3 (0.49) | NOTUMKDM4ECYP2C19USP2HPGD | |
| SCHEMBL25146908 | 0.77 | ACACB (0.49) | NOTUMKDM4ECYP2C19USP2HPGD | |
| SCHEMBL23103150 | 0.77 | NOTUM (0.49) | NOTUMKDM4ECYP2C19USP2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |