Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.31 |
| ▸ | FEN1 | P39748 | 2/20 | 0.31 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | GCKR | Q14397 | 2/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | GABRP | O00591 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18291377 | 0.84 | DRD3 (0.48) | DRD3KCNH2CHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL20037981 | 0.84 | DRD3 (0.33) | DRD3KCNH2ALDH1A1GAAATM | |
| SCHEMBL20249159 | 0.81 | DRD3 (0.33) | DRD3KCNH2AKR1C3 | |
| SCHEMBL24179944 | 0.80 | MAPT (0.50) | DRD3KCNH2CHRNB2CHRNA4SMN1; SMN2 | |
| SCHEMBL2820372 | 0.79 | SLC6A2 (0.44) | MTORDRD3KCNH2CHRNB2CHRNA4 | |
| SCHEMBL22813083 | 0.78 | TRPC6 (0.42) | MTORCHRNB2CHRNA4KDM4EGCK | |
| SCHEMBL1393916 | 0.75 | GABRP (0.39) | KCNH2CHRNB2CHRNA4KDM4EALDH1A1 | |
| SCHEMBL29813620 | 0.75 | GAA (0.40) | MTORDRD3KCNH2KDM4EALDH1A1 | |
| SCHEMBL24525802 | 0.75 | GAA (0.40) | MTORDRD3KCNH2KDM4EALDH1A1 | |
| SCHEMBL17055336 | 0.75 | HRH3 (0.39) | MTORDRD3KCNH2CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |