Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.60 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.60 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | QPCT | Q16769 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20038153 | 0.83 | TPSAB1 (0.64) | TPSAB1TPSD1TPSG1HTTALDH1A1 | |
| SCHEMBL28371857 | 0.82 | RAB9A (0.47) | TPSAB1TPSD1TPSG1HTTSCN7A | |
| SCHEMBL20249273 | 0.81 | PANK3 (0.45) | TPSAB1TPSD1TPSG1KMT2AMEN1 | |
| SCHEMBL20038188 | 0.81 | TPSAB1 (0.64) | TPSAB1TPSD1TPSG1SCN7AKCNH2 | |
| SCHEMBL18291283 | 0.80 | TPSAB1 (0.60) | TPSAB1TPSD1TPSG1SCN7AKCNH2 | |
| SCHEMBL27956550 | 0.80 | TPSAB1 (0.76) | TPSAB1TPSD1TPSG1HTTALDH1A1 | |
| SCHEMBL20255382 | 0.78 | TPSAB1 (0.43) | TPSAB1TPSD1TPSG1TSHRTDP1 | |
| SCHEMBL654109 | 0.77 | TPSAB1 (0.76) | TPSAB1TPSD1TPSG1ALDH1A1KMT2A | |
| SCHEMBL656573 | 0.76 | TPSAB1 (0.78) | TPSAB1TPSD1TPSG1ALDH1A1KMT2A | |
| SCHEMBL3787327 | 0.75 | SMN1; SMN2 (0.60) | TSHRALDH1A1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | TEIJIN PHARMA LIMITED (JP) | 2018-06-14 | — | — | US | disclosed |
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | CDK4, CDK6, CDK16 | TPSAB1 3489/4885TPSD1 2373/4885TPSG1 4128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.