Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | PANK3 | Q9H999 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20037551 | 0.86 | ALDH1A1 (0.55) | LTA4H | |
| SCHEMBL20203580 | 0.85 | ALDH1A1 (0.50) | PRMT5WDR77PDCD1CD274LTA4H | |
| SCHEMBL4547913 | 0.80 | HRH3 (0.50) | PRMT5WDR77HRH3 | |
| SCHEMBL12028959 | 0.80 | HRH3 (0.47) | PRMT5WDR77CD274PANK3HRH3 | |
| SCHEMBL18291572 | 0.80 | BRD4 (0.45) | PDCD1CD274LTA4HBRD4MEN1 | |
| SCHEMBL12041186 | 0.78 | HRH3 (0.45) | PRMT5WDR77NR1H2NR1H3LTA4H | |
| SCHEMBL25896863 | 0.78 | HRH3 (0.53) | HRH3MEN1KMT2A | |
| SCHEMBL20203465 | 0.77 | HRH3 (0.50) | PRMT5WDR77LTA4HHRH3MEN1 | |
| SCHEMBL17660303 | 0.77 | LMNA (0.50) | PRMT5WDR77HRH3MEN1KMT2A | |
| SCHEMBL20203451 | 0.77 | ALDH1A1 (0.51) | PRMT5WDR77MEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |