Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24299592 | 0.83 | PIK3CA (0.40) | MAP4K4KMT2APDE10APIK3CAMTOR | |
| SCHEMBL20255696 | 0.79 | CHRNB2 (0.35) | MAP4K4CHRNB2CHRNA4KMT2APDE10A | |
| SCHEMBL18291295 | 0.79 | NR1I2 (0.46) | CHRNB2CHRNA4KMT2APDE10ACHRNA7 | |
| SCHEMBL23603294 | 0.79 | CHRNB2 (0.57) | CHRNB2CHRNA4KMT2ACHRNB4CHRNA3 | |
| SCHEMBL20929736 | 0.79 | KMT2A (0.36) | CHRNB2CHRNA4KMT2ACHRNA7HTR3A | |
| SCHEMBL20249344 | 0.76 | KMT2A (0.36) | MAP4K4CHRNB2CHRNA4KMT2APDE10A | |
| SCHEMBL18291519 | 0.73 | NR1I2 (0.38) | MAP4K4KMT2A | |
| SCHEMBL20929741 | 0.72 | KMT2A (0.66) | KMT2APIK3CAMTOR | |
| SCHEMBL11636168 | 0.72 | KMT2A (0.66) | KMT2APIK3CAMTOR | |
| SCHEMBL20929744 | 0.72 | KMT2A (0.41) | CHRNB2CHRNA4KMT2ACHRNA7HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |