Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 13/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 13/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18819902 | 0.91 | PDCD1 (0.52) | PDCD1CD274CDK4CDK1CDK2 | |
| SCHEMBL19674803 | 0.79 | DRD1 (0.40) | KDM4EALDH1A1MAPT | |
| SCHEMBL21414409 | 0.77 | PNMT (0.44) | PDCD1CD274CDK4CDK1CDK2 | |
| SCHEMBL18291672 | 0.75 | ADRA1B (0.45) | PDCD1CD274 | |
| SCHEMBL18291660 | 0.74 | CDK4 (0.44) | PDCD1CD274CDK4CDK1CDK2 | |
| SCHEMBL21452319 | 0.74 | CDK4 (0.42) | PDCD1CD274CDK4CDK2CDK6 | |
| SCHEMBL21414365 | 0.74 | PDCD1 (0.47) | PDCD1CD274CDK4CDK1CDK2 | |
| SCHEMBL18820431 | 0.74 | CDK4 (0.42) | PDCD1CD274KDM4ECDK4CDK1 | |
| SCHEMBL20037477 | 0.74 | PDCD1 (0.47) | PDCD1CD274CDK4CDK1CDK2 | |
| SCHEMBL20255719 | 0.73 | PDCD1 (0.47) | PDCD1CD274CDK4CDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |