Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 1/20 | 0.63 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | TLR2 | O60603 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.33 |
| ▸ | LPAR3 | Q9UBY5 | 4/20 | 0.33 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11516779 | 0.89 | DNM1 (0.61) | DNM1ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL15504875 | 0.86 | DNM1 (0.50) | DNM1ALDH1A1TDP1HTT | |
| SCHEMBL11205740 | 0.85 | DNM1 (0.48) | DNM1ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL10003570 | 0.84 | DNM1 (0.50) | DNM1ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL15286858 | 0.84 | DNM1 (0.48) | DNM1ALDH1A1TDP1CYP3A4 | |
| SCHEMBL31481827 | 0.83 | DNM1 (0.77) | DNM1ALDH1A1HTTCNR1CNR2 | |
| SCHEMBL25872066 | 0.83 | DNM1 (0.77) | DNM1ALDH1A1HTTCNR1CNR2 | |
| SCHEMBL13978176 | 0.83 | DNM1 (0.77) | DNM1ALDH1A1HTTCNR1CNR2 | |
| SCHEMBL8202515 | 0.81 | DNM1 (0.45) | DNM1ADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL13326798 | 0.81 | DNM1 (0.45) | DNM1ADRB2ADRB1ADRB3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3091012-B1 | CCR2 RECEPTOR ANTAGONISTS AND USES THEREOF | CENTREXION THERAPEUTICS CORP (US) | 2018-04-11 | — | — | EP | disclosed |