Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5844147 | 0.81 | MAPK1 (0.46) | ALDH1A1HSD17B10RAB9ACA12CA1 | |
| SCHEMBL27284948 | 0.77 | MAPK1 (0.50) | SMN1; SMN2ALDH1A1HSD17B10RAB9ACYP1A2 | |
| SCHEMBL2743309 | 0.72 | ALDH1A1 (0.43) | ALDH1A1HSD17B10CYP1A2KMT2AKDM4E | |
| SCHEMBL4538724 | 0.71 | MAPT (0.43) | SMN1; SMN2ALDH1A1RECQLRAB9ACA12 | |
| SCHEMBL8880069 | 0.71 | DPP4 (0.44) | SMN1; SMN2ALDH1A1HSD17B10RAB9ACYP1A2 | |
| SCHEMBL27289016 | 0.71 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1HSD17B10RAB9ACYP1A2 | |
| SCHEMBL1748473 | 0.70 | MAPK1 (0.46) | ALDH1A1HSD17B10RAB9ACA12CA1 | |
| SCHEMBL15155090 | 0.70 | ADORA3 (0.49) | SMN1; SMN2ALDH1A1RAB9ACA12CA1 | |
| SCHEMBL7374513 | 0.70 | MAPK1 (0.47) | SMN1; SMN2ALDH1A1HSD17B10RAB9ACA12 | |
| SCHEMBL10004608 | 0.69 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1HSD17B10RAB9ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3091012-B1 | CCR2 RECEPTOR ANTAGONISTS AND USES THEREOF | CENTREXION THERAPEUTICS CORP (US) | 2018-04-11 | — | — | EP | disclosed |