SCHEMBL20040128

SCHEMBL20040128

Cc1cnc(-c2ncc(N)s2)s1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS1 P29475 1/20 0.54
ADORA2A P29274 3/20 0.34
ADORA1 P30542 3/20 0.34
SRC P12931 1/20 0.34
CDK2 P24941 1/20 0.34
ZAP70 P43403 1/20 0.34
SYK P43405 1/20 0.34
HDAC4 P56524 1/20 0.34
ADORA3 P0DMS8 2/20 0.32
ADORA2B P29275 2/20 0.32
KDR P35968 1/20 0.31
FDPS P14324 1/20 0.31
ALDH1A1 P00352 1/20 0.30
POLB P06746 1/20 0.30
MAPT P10636 1/20 0.30
THRB P10828 1/20 0.30
HTT P42858 1/20 0.30
RECQL P46063 1/20 0.30
HSD17B10 Q99714 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15998127 0.85 NOS1 (0.36) NOS1ALDH1A1
SCHEMBL10002194 0.85 NOS1 (0.55) NOS1ADORA2AADORA1SRCCDK2
SCHEMBL13191843 0.73 NOS1 (0.43) NOS1ADORA2AADORA1SRCCDK2
SCHEMBL31219241 0.72 NOS1 (0.48) NOS1ADORA2AADORA1SRCCDK2
SCHEMBL1207018 0.71 ALDH1A1 (0.47) NOS1ADORA2AADORA1HDAC4ADORA3
SCHEMBL17890 0.70
SCHEMBL160815 0.70
SCHEMBL20175446 0.70 NOS1 (0.44) NOS1ADORA2AADORA1SRCCDK2
SCHEMBL2629268 0.70 ADORA2A (0.45) NOS1ADORA2AADORA1SRCCDK2
SCHEMBL3714018 0.69 NOS1 (0.44) NOS1ADORA2AADORA1SRCCDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3306690-B1 ORGANIC SEMICONDUCTING COMPOUNDS RAYNERGY TEK INC (TW) 2022-09-07 EP disclosed
EP-3306690-A1 ORGANIC SEMICONDUCTING COMPOUNDS Merck Patent GmbH (DE) 2018-04-11 EP disclosed