Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 2/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 5/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 3/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13528293 | 0.86 | AR (0.40) | IDO1ARSLC22A12KIF11PDK2 | |
| SCHEMBL1421027 | 0.86 | AR (0.50) | IDO1ARSLC22A12KIF11KDR | |
| SCHEMBL22549095 | 0.82 | AR (0.41) | IDO1ARSLC22A12KIF11PDK2 | |
| SCHEMBL19266264 | 0.79 | AR (0.36) | IDO1ARSLC22A12KIF11PDK2 | |
| SCHEMBL8167857 | 0.73 | KIF11 (0.50) | ARKIF11 | |
| SCHEMBL13528298 | 0.73 | CFTR (0.40) | ARSLC22A12KIF11PDK2KCNH2 | |
| SCHEMBL31099069 | 0.73 | RAPGEF4 (0.50) | IDO1KIF11KCNH2 | |
| SCHEMBL1421215 | 0.73 | RAPGEF4 (0.50) | IDO1KIF11KCNH2 | |
| SCHEMBL15117064 | 0.72 | SMN1; SMN2 (0.41) | IDO1RXRAGRIN1GRIN2BKCNH2 | |
| SCHEMBL14267822 | 0.72 | AR (0.49) | ARKIF11KDRPDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864289-B1 | CYCLOPROPANECARBOXAMIDO-SUBSTITUTED AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS | CB THERAPEUTICS INC (KY) | 2018-04-11 | — | — | EP | disclosed |