Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 7/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | CDK8 | P49336 | 3/20 | 0.38 |
| ▸ | RET | P07949 | 3/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | PAK4 | O96013 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043643 | 0.83 | DYRK1B (0.46) | DYRK1BDYRK1AJAK2CDK8RET | |
| SCHEMBL4042767 | 0.82 | KDM4E (0.48) | DYRK1BDYRK1AMAPK1JAK2CDK8 | |
| SCHEMBL31398027 | 0.81 | DYRK1B (0.42) | DYRK1BDYRK1AJAK2CDK8RET | |
| SCHEMBL16537120 | 0.81 | MAPK1 (0.40) | DYRK1BDYRK1AMAPK1JAK2CDK8 | |
| SCHEMBL12168140 | 0.77 | ALDH1A1 (0.41) | DYRK1BDYRK1AJAK2CDK8RET | |
| SCHEMBL14002611 | 0.77 | KDM4E (0.50) | MAPK1OPRK1 | |
| SCHEMBL12370605 | 0.76 | MEN1 (0.38) | DYRK1BDYRK1AMAPK1JAK2CDK8 | |
| SCHEMBL29495723 | 0.76 | MEN1 (0.38) | DYRK1BDYRK1AMAPK1JAK2CDK8 | |
| SCHEMBL13386937 | 0.76 | YTHDC1 (0.63) | YTHDC1DYRK1APAK1JAK2AURKB | |
| SCHEMBL22208455 | 0.75 | DYRK1A (0.51) | DYRK1APAK1GSK3BOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305073-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | Samumed, LLC (US) | 2018-04-11 | — | — | EP | disclosed |