SCHEMBL20042759

SCHEMBL20042759

Cc1nc2c(c(N3CC(F)C3)n1)CNC2

nearest known ligand 0.35

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CHRM3 P20309 1/20 0.35
PDE4A P27815 1/20 0.35
PDE4B Q07343 1/20 0.35
PDE4C Q08493 1/20 0.35
PDE4D Q08499 1/20 0.35
CYP1A2 P05177 1/20 0.32
PSD A5PKW4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20042683 0.79 NPY5R (0.39) CHRM3PDE4APDE4BPDE4CPDE4D
SCHEMBL31614818 0.79 NPY5R (0.39) CHRM3PDE4APDE4BPDE4CPDE4D
Hydrochloric Acid SCHEMBL31614730 0.78 MEN1 (0.39) CHRM3PDE4APDE4BPDE4CPDE4D
Hydrochloric Acid SCHEMBL31405518 0.78 MEN1 (0.39) CHRM3PDE4APDE4BPDE4CPDE4D
SCHEMBL22727886 0.75 MTOR (0.47)
SCHEMBL20042677 0.71 NPY5R (0.34)
SCHEMBL20042682 0.71 NPY5R (0.34)
SCHEMBL17297899 0.68 HTR2A (0.33) CYP1A2
SCHEMBL15859967 0.65
SCHEMBL20042661 0.65

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018066718-A1 THERAPEUTIC COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2018-04-12 WO disclosed