Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2006557 | 0.91 | GAA (0.39) | KMT2AHPGDALDH1A1SMN1; SMN2PIK3CA | |
| SCHEMBL2000002 | 0.87 | HPGD (0.47) | HSD17B10KMT2AHPGDALDH1A1PIK3CA | |
| SCHEMBL2007330 | 0.87 | EPHX2 (0.47) | HPGDALDH1A1SMN1; SMN2PIK3CAKCNH2 | |
| SCHEMBL2002032 | 0.84 | HSD11B1 (0.35) | KMT2AHPGDALDH1A1SMN1; SMN2HSD11B1 | |
| SCHEMBL2001530 | 0.82 | CRHBP (0.44) | NPC1LIPEHSD17B10KMT2AALDH1A1 | |
| SCHEMBL2008902 | 0.80 | CPT1A (0.35) | HSD17B10ALDH1A1SMN1; SMN2PIK3CA | |
| SCHEMBL2007329 | 0.78 | KMT2A (0.41) | NPC1KMT2AALDH1A1RAB9A | |
| SCHEMBL2001763 | 0.78 | CNR2 (0.34) | ALDH1A1PIK3CATSHRKCNH2LMNA | |
| SCHEMBL2001814 | 0.78 | CNR1 (0.40) | HSD17B10ALDH1A1SMN1; SMN2PIK3CA | |
| SCHEMBL2005665 | 0.78 | HTT (0.37) | HSD17B10ALDH1A1SMN1; SMN2PIK3CALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960377-B2 | Substituted pyridoxazines | CARA THERAPEUTICS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| US-20090247502-A1 | SUBSTITUTED PYRIDOXAZINES | CARA THERAPEUTICS, INC. (US) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247502-A1 | SUBSTITUTED PYRIDOXAZINES | CNR1, CNR2, TRPV1 | NPC1 1554/4885LIPE 2312/4885HSD17B10 3023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.