SCHEMBL20043889

SCHEMBL20043889

CN1C[C@H](c2ccc(C#N)cc2)[C@@H](C(=O)Nc2cccc(F)c2F)C1=O

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
RORC P51449 1/20 0.38
TP53 P04637 1/20 0.38
MEN1 O00255 1/20 0.38
MAPT P10636 1/20 0.38
KMT2A Q03164 1/20 0.38
FPR2 P25090 1/20 0.36
GPR6 P46095 2/20 0.35
ALDH1A1 P00352 2/20 0.35
LMNA P02545 1/20 0.35
GRIA2 P42262 1/20 0.35
KCNH2 Q12809 1/20 0.35
EPHX2 P34913 1/20 0.35
CHRM3 P20309 1/20 0.34
CCKAR P32238 1/20 0.34
CCKBR P32239 1/20 0.34
EP300 Q09472 2/20 0.34
KDM1A O60341 2/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
MAOB P27338 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20048611 0.92 MEN1 (0.46) RORCMEN1MAPTKMT2AFPR2
SCHEMBL20048590 0.91 ALDH1A1 (0.41) MEN1MAPTKMT2AALDH1A1EPHX2
SCHEMBL20048585 0.90 TP53 (0.37) TP53MEN1MAPTKMT2AGPR6
SCHEMBL20044728 0.88 TP53 (0.35) TP53MEN1MAPTKMT2AFPR2
SCHEMBL21013006 0.88 TP53 (0.40) TP53MEN1MAPTKMT2AALDH1A1
SCHEMBL20048521 0.87 TP53 (0.36) TP53MEN1MAPTKMT2AGPR6
SCHEMBL20048483 0.87 TP53 (0.36) RORCTP53MEN1MAPTKMT2A
SCHEMBL20048487 0.87 ALDH1A1 (0.46) TP53MEN1MAPTKMT2AALDH1A1
SCHEMBL20044724 0.86 TP53 (0.35) RORCTP53MEN1MAPTKMT2A
SCHEMBL20044436 0.86 TP53 (0.39) TP53MEN1MAPTKMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 RORC 3398/4885TP53 1193/4885MEN1 3340/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 RORC 3398/4885TP53 1193/4885MEN1 3340/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 RORC 3398/4885TP53 1193/4885MEN1 3340/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 RORC 3386/4885TP53 1230/4885MEN1 3362/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 RORC 3398/4885TP53 1193/4885MEN1 3340/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 RORC 3398/4885TP53 1193/4885MEN1 3340/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 RORC 3398/4885TP53 1193/4885MEN1 3340/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.