SCHEMBL2004390

SCHEMBL2004390

CCCCNC[Si](C)(C)C

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.52
ALDH1A1 P00352 1/20 0.48
ADH1B P00325 2/20 0.40
ADH1C P00326 2/20 0.40
ADH1A P07327 2/20 0.40
ADH7 P40394 2/20 0.40
CYP2C19 P33261 2/20 0.35
MEN1 O00255 1/20 0.35
GLA P06280 1/20 0.35
KMT2A Q03164 1/20 0.35
CA1 P00915 2/20 0.35
CA2 P00918 2/20 0.35
CA12 O43570 1/20 0.35
CA7 P43166 1/20 0.35
CA14 Q9ULX7 1/20 0.35
HRH4 Q9H3N8 3/20 0.33
HRH3 Q9Y5N1 3/20 0.33
EPHX1 P07099 2/20 0.33
CYP1A2 P05177 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18112242 0.85 CYP2C19 (0.40) TSHRALDH1A1CYP2C19MEN1GLA
SCHEMBL16775511 0.81 CYP2C19 (0.60) TSHRALDH1A1CYP2C19MEN1GLA
SCHEMBL4525565 0.79 TSHR (0.48) TSHRALDH1A1ADH1BADH1CADH1A
SCHEMBL28088405 0.76 CA12 (0.52) TSHRALDH1A1CYP2C19MEN1KMT2A
SCHEMBL4518806 0.76 TSHR (0.50) TSHRALDH1A1ADH1BADH1CADH1A
SCHEMBL432428 0.76 TSHR (0.52) TSHRALDH1A1ADH1BADH1CADH1A
SCHEMBL555017 0.75 TSHR (0.44) TSHRALDH1A1ADH1BADH1CADH1A
SCHEMBL21496029 0.75 TSHR (0.44) TSHRALDH1A1ADH1BADH1CADH1A
SCHEMBL2532 0.75
SCHEMBL27946380 0.75 TSHR (0.79) TSHRALDH1A1ADH1BADH1CADH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106010150-B Thermosetting powder coating and coating product 富士施乐株式会社 2019-10-11 CN disclosed
US-20180133749-A1 METHOD FOR PRODUCING COATED ARTICLE FUJI XEROX CO., LTD. (JP) 2018-05-17 US disclosed
US-20170087584-A1 ELECTROSTATIC POWDER COATING METHOD AND POWDER COATING MATERIAL FUJI XEROX CO., LTD. (JP) 2017-03-30 US disclosed
CN-106010150-A Thermosetting powder coating and coated article 富士施乐株式会社 2016-10-12 CN disclosed
EP-2240492-B1 PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS ORGANON NV (NL) 2011-10-05 EP disclosed
US-20110166363-A1 PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS FOREST LABORATORIES HOLDINGS LIMITED (BM) 2011-07-07 US disclosed
US-7964739-B2 Through a stilbene derivative, to a pyrrolidine intermediate, followed by cyclization; asenapine is an antipsychotic agent; industrial scale N.V. ORGANON (NL) 2011-06-21 US disclosed
EP-2240492-A1 PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS N.V. Organon (NL) 2010-10-20 EP disclosed
US-20090227803-A1 PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS N.V. ORGANON 2009-09-10 US disclosed
WO-2009087058-A1 PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS N.V. ORGANON (NL) 2009-07-16 WO disclosed
CN-101108825-A Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists MERCK & CO INC (US) 2008-01-23 CN disclosed
CN-1768041-A Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists MERCK & CO INC (US) 2006-05-03 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110166363-A1 PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS DHPS, CYP3A5, PNMT TSHR 3446/4885ALDH1A1 600/4885ADH1B 134/4885
US-20090227803-A1 PROCESS FOR THE PREPARATION OF ASENAPINE AND INTERMEDIATE PRODUCTS USED IN SAID PROCESS DHPS, CYP3A5, PNMT TSHR 3446/4885ALDH1A1 600/4885ADH1B 134/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.