Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ADH1B | P00325 | 1/20 | 0.38 |
| ▸ | ADH1C | P00326 | 1/20 | 0.38 |
| ▸ | ADH1A | P07327 | 1/20 | 0.38 |
| ▸ | ADH4 | P08319 | 1/20 | 0.38 |
| ▸ | ADH7 | P40394 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22471943 | 0.85 | OPRM1 (0.50) | OPRM1SPHK1LMNADNM1TSHR | |
| SCHEMBL16779862 | 0.85 | OPRM1 (0.50) | OPRM1SPHK1LMNADNM1TSHR | |
| SCHEMBL7122697 | 0.82 | OPRM1 (0.52) | OPRM1SPHK1LMNADNM1TSHR | |
| SCHEMBL14778098 | 0.78 | OPRM1 (0.44) | OPRM1SPHK1LMNADNM1TSHR | |
| Heptane SCHEMBL1323676 | 0.77 | TSHR (0.44) | OPRM1SPHK1LMNADNM1TSHR | |
| SCHEMBL25220046 | 0.76 | SPHK1 (0.50) | OPRM1SPHK1LMNAACE2GPR84 | |
| SCHEMBL25350097 | 0.76 | SPHK1 (0.50) | OPRM1SPHK1LMNAACE2GPR84 | |
| SCHEMBL18569423 | 0.75 | OPRM1 (0.46) | OPRM1SPHK1LMNADNM1TSHR | |
| SCHEMBL24581697 | 0.75 | OPRM1 (0.46) | OPRM1SPHK1LMNADNM1TSHR | |
| SCHEMBL28143315 | 0.75 | OPRM1 (0.46) | OPRM1SPHK1LMNADNM1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067424-A1 | INHIBITORS OF ADENOSINE 5'-NUCLEOTIDASE | ARCUS BIOSCIENCES, INC. (US) | 2018-04-12 | — | — | WO | disclosed |